The following is a summary of “Epidemiology, characteristics, and prognostic factors of lymphoplasmacytic-rich meningioma: a systematic literature review,” published in the January 2024 issue of Oncology by Zhu et al.
Lymphoplasmacyte-rich meningioma (LPM), a rare and comparatively less malignant subtype of meningioma, holds an overall favorable prognosis. This article aims to enhance comprehension of the disease, mitigate misdiagnosis, and refine prognostic understanding. Employing a systematic approach, researchers conducted a comprehensive search on the PubMed database, spanning English articles from 1993 to 2023, with specific keywords related to lymphoplasmacyte-rich meningioma. The analysis explored clinical manifestations, imaging features, pathological characteristics, treatment modalities, and prognostic indicators. Their investigation included 95 LPM patients from fourteen reports, comprising 47 males and 48 females with an age range of 9 to 79 years and an average age of 45.
Predominant clinical manifestations featured headaches and limb movement disorders, with tumors predominantly located on the convex portion of the brain. Notably, all tumors exhibited significant enhancement, with homogeneous enhancement being more prevalent, and most patients demonstrated peritumoral edema. Postoperative pathological assessments, including EMA, LCA, and vimentin positivity, proved instrumental in final diagnosis confirmation. Prognostic evaluations employing log-rank tests underscored a correlation between complete tumor resection and improved prognosis with lower recurrence rates. In conclusion, while clinical symptoms and imaging manifestations of LPM lack significant distinctions from other differentiable diseases, an unequivocal diagnosis necessitates thorough pathological examination.
Standardized surgical interventions contribute to a notable reduction in recurrence and mortality rates for LPM, emphasizing the pivotal role of complete tumor resection in achieving better prognostic outcomes. These findings underscore the importance of a multidisciplinary approach for a nuanced understanding and effective management of lymphoplasmacytic-rich meningioma.
Source: bmccancer.biomedcentral.com/articles/10.1186/s12885-023-11811-4