Immunocompromised adults hospitalized with COVID-19 have increased odds of ICU admission and in-hospital death regardless of vaccination status, according to research published in Morbidity and Mortality Weekly Report. James Meek, MPH, and colleagues examined the associations between immunocompromise and ICU admission and in-hospital death, as well as between COVID-19 vaccination status and ICU admission and in-hospital death. During the study period, 12.2% of 22,345 adults hospitalized for COVID-19 were immunocompromised. Among unvaccinated patients, the odds of ICU admission and in-hospital death were higher for those who were immunocompromised versus not immunocompromised (adjusted ORs, 1.26 and 1.34, respectively). Among vaccinated patients, the odds were also increased for ICU admission and in-hospital death for immunocompromised patients versus patients who were not immunocompromised (adjusted ORs, 1.40 and 1.87, respectively). Among patients who were not immunocompromised, the odds of death were lower for vaccinated versus unvaccinated patients (adjusted OR, 0.58). For immunocompromised patients, the odds of death did not differ by vaccination status.
