A real-life quality improvement project investigated the impact of a general practitioner-led medication review intervention focusing on deprescribing on health-related outcomes. Anne Estrup Olesen, MD, and colleagues conducted a study involving nursing home residents and community-dwelling patients seen at a large g eneral practice. The primary outcomes were changes in self-reported health status, general condition, and functional level from baseline to 3-4months follow-up. The researchers found that 83% of medication changes were linked with deprescribing. Results showed an increase in mean self-reported health status by 0.55 (95% CI; 0.22 to 0.87) from baseline to follow-up. The proportion of patients with a general condition rated as ‘average or above’ remained stable, with a slight increase of 0.06 (95% CI; -0.02 to 0.14). Additionally, the proportion of patients with a functional level ‘without any disability’ remained stable, with a slight decrease of -0.05 (95% CI; -0.09 to 0.001).