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The following is a summary of “Cell-integrated serum-induced signalling patterns can differentiate between hand and knee osteoarthritis patients,” published in the November 2024 issue of Hematology by Neefjes et al.
Researchers conducted a retrospective study to differentiate patients with osteoarthritis (OA) based on their serum-induced cell-integrated signaling patterns.
They analyzed the response of human OA serum samples using 16 cell-based transcription factor luciferase reporter assays. Serum samples from 55 patients with knee OA, 56 patients with hand OA, and 42 healthy controls were compared.
The results showed differential serum-induced pathway activity between healthy controls, knee OA, and patients with hand OA. Hand OA serum-induced high MAPK-related AP1 activity, while knee OA serum increased SRE, ISRE, and SOX9 activity. Principal component analysis differentiated hand OA from knee OA, with each clustering into distinct endotypes, but no subtypes were identified within the groups.
They showed that serum from hand and knee patients with OA induced distinct signaling patterns, highlighting different pathomolecular mechanisms. This finding may inform OA endotype-specific therapies.
Source: academic.oup.com/rheumatology/advance-article/doi/10.1093/rheumatology/keae555/7903293
