A higher incidence of cardiovascular disease (CVD) is linked with an earlier diagnosis of T2D, according to a study in Diabetes Care. Kyong Soo Park, MD, and colleagues examined the genetic risk for CVD based on age of diagnosis of T2D, using data from the UK Biobank (N=12,321) and the Seoul National University Hospital (SNUH) cohort (N=1,165). Polygenic risk score (PRS) was used to quantify genetic risk. The effect size of coronary artery disease
(CAD) PRS on incident CAD was largest in the UK Biobank in people diagnosed with T2D at ages 30-39 (HR, 2.25; 95% CI, 1.56–3.26) and decreased as age at diagnosis increased: ages 40-49 (1.51; 1.30–1.75), 50-59 (1.36; 1.24–1.50), and 60-69 (1.30; 1.14–1.48). In the SNUH cohort, a similar trend was noted. The study authors observed that this increased genetic risk link with earlier T2D diagnosis “was largely mitigated by a healthy lifestyle. This information could be used to tailor lifestyle interventions.”
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