Researchers conducted 26 systematic reviews, encompassing 338 original studies that evaluated the efficacy of eHealth interventions for weight loss and maintenance among adults with overweight or obesity. The findings, which Current Obesity Reports published online, suggest that eHealth interventions are comparable to face-toface interventions and more effective than control interventions or no care. While the effect on sizes remains relatively small, ranging from−0.12 kg to−4.32 kg in weight loss outcomes, the overall trend favors eHealth interventions. Notably, interventions with human contact, such as personalized feedback provided by healthcare professionals, yielded better results than fully automated interventions. The methodological quality of the included studies varied, with some demonstrating moderate to low quality. However, despite this variability, the evidence underscores the potential of eHealth interventions in addressing the challenges of obesity care, particularly in reaching a larger population economically.