Past 30-day electronic nicotine delivery systems (ENDS) use among adults is associated with earlier ages of asthma onset, according to a study in JAMA Network Open. Adriana Pérez, PhD, and colleagues explored the association of past 30-day ENDS use with the age of asthma onset in adults and young patients who did not have asthma COPD and never used cigarettes. The analysis included 24,789 participants in the Population of Tobacco and Health Study (2013-2021). By age 27, 6.2 per 1,000 adults reported asthma incidence. For adults who used ENDS in the past 30 days, when controlling for covariates, there was an increased risk for asthma onset at earlier ages compared with adults who did not use ENDS (aHR, 3.52; 95% CI, 1.24-10.02). Given their findings, Dr. Pérez and colleagues recommended prevention and cessation programs for adults who use ENDS.