Electrospun polyamide-6/chitosan nanofibers reinforced nano-hydroxyapatite/polyamide-6 composite bilayered membranes for guided bone regeneration.

Mar 15, 2021

Contributor: Xiaolian Niu,Longfei Wang,Mengjie Xu,Miao Qin,Liqin Zhao,Yan Wei,Yinchun Hu,Xiaojie Lian,Ziwei Liang,Song Chen,Weiyi Chen,Di Huang

Electrospun polyamide-6/chitosan nanofibers reinforced nano-hydroxyapatite/polyamide-6 composite bilayered membranes for guided bone regeneration.

Periodontal defect poses a significant challenge in orthopedics. Guided Bone Regeneration (GBR) membrane is considered as one of the most successful methods applied to reconstruct alveolar bone and then to achieve periodontal defect repair/regeneration. In this paper, a novel polyamide-6/chitosan@nano-hydroxyapatite/polyamide-6 (PA6/CS@n-HA/PA6) bilayered tissue guided membranes by combining a solvent casting and an electrospinning technique was designed. The developed PA6/CS@n-HA/PA6 composites were characterized by a series of tests. The results show that n-HA/PA6 and electrospun PA6/CS layers are tightly bound by molecular interaction and chemical bonding, which enhances the bonding strength between two distinct layers. The porosity and adsorption average pore diameter of the PA6/CS@n-HA/PA6 membranes are 36.90 % and 22.61 nm, respectively. The tensile strength and elastic modulus of PA6/CS@n-HA/PA6 composites are 1.41 ± 0.18 MPa and 7.15 ± 1.09 MPa, respectively. In vitro cell culture studies demonstrate that PA6/CS@n-HA/PA6 bilayered scaffolds have biological safety, good bioactivity, biocompatibility and osteoconductivity.
Copyright © 2021 Elsevier Ltd. All rights reserved.

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About The Expert

Xiaolian Niu

Research Center for Nano-biomaterials & Regenerative Medicine, Department of Biomedical Engineering, College of Biomedical Engineering, Taiyuan University of Technology, Taiyuan, 030024, China.

Longfei Wang

Research Center for Nano-biomaterials & Regenerative Medicine, Department of Biomedical Engineering, College of Biomedical Engineering, Taiyuan University of Technology, Taiyuan, 030024, China.

Mengjie Xu

Research Center for Nano-biomaterials & Regenerative Medicine, Department of Biomedical Engineering, College of Biomedical Engineering, Taiyuan University of Technology, Taiyuan, 030024, China.

Miao Qin

Research Center for Nano-biomaterials & Regenerative Medicine, Department of Biomedical Engineering, College of Biomedical Engineering, Taiyuan University of Technology, Taiyuan, 030024, China.

Liqin Zhao

Research Center for Nano-biomaterials & Regenerative Medicine, Department of Biomedical Engineering, College of Biomedical Engineering, Taiyuan University of Technology, Taiyuan, 030024, China; Institute of Biomedical Engineering, Shanxi Key Labratory of Materials Strength & Structrual Impact, Taiyuan University of Technology, Taiyuan, 030024, China.

Yan Wei

Research Center for Nano-biomaterials & Regenerative Medicine, Department of Biomedical Engineering, College of Biomedical Engineering, Taiyuan University of Technology, Taiyuan, 030024, China; Institute of Biomedical Engineering, Shanxi Key Labratory of Materials Strength & Structrual Impact, Taiyuan University of Technology, Taiyuan, 030024, China.

Yinchun Hu

Research Center for Nano-biomaterials & Regenerative Medicine, Department of Biomedical Engineering, College of Biomedical Engineering, Taiyuan University of Technology, Taiyuan, 030024, China; Institute of Biomedical Engineering, Shanxi Key Labratory of Materials Strength & Structrual Impact, Taiyuan University of Technology, Taiyuan, 030024, China.

Xiaojie Lian

Research Center for Nano-biomaterials & Regenerative Medicine, Department of Biomedical Engineering, College of Biomedical Engineering, Taiyuan University of Technology, Taiyuan, 030024, China; Institute of Biomedical Engineering, Shanxi Key Labratory of Materials Strength & Structrual Impact, Taiyuan University of Technology, Taiyuan, 030024, China.

Ziwei Liang

Research Center for Nano-biomaterials & Regenerative Medicine, Department of Biomedical Engineering, College of Biomedical Engineering, Taiyuan University of Technology, Taiyuan, 030024, China.

Song Chen

Research Center for Nano-biomaterials & Regenerative Medicine, Department of Biomedical Engineering, College of Biomedical Engineering, Taiyuan University of Technology, Taiyuan, 030024, China; Institute of Biomedical Engineering, Shanxi Key Labratory of Materials Strength & Structrual Impact, Taiyuan University of Technology, Taiyuan, 030024, China.

Weiyi Chen

Research Center for Nano-biomaterials & Regenerative Medicine, Department of Biomedical Engineering, College of Biomedical Engineering, Taiyuan University of Technology, Taiyuan, 030024, China; Institute of Biomedical Engineering, Shanxi Key Labratory of Materials Strength & Structrual Impact, Taiyuan University of Technology, Taiyuan, 030024, China.

Di Huang

Research Center for Nano-biomaterials & Regenerative Medicine, Department of Biomedical Engineering, College of Biomedical Engineering, Taiyuan University of Technology, Taiyuan, 030024, China; Institute of Biomedical Engineering, Shanxi Key Labratory of Materials Strength & Structrual Impact, Taiyuan University of Technology, Taiyuan, 030024, China. Electronic address: huangjw2067@163.com.

References

PubMed