Asthma is a widespread disease characterized by chronic airway inflammation. It causes substantial disability, impaired quality of life, and avoidable deaths around the world. The main treatment for asthmatic patients is the administration of corticosteroids, which improves the quality of life; however, prolonged use of corticosteroids interferes with extracellular matrix elements. Therefore, cell-based therapies are emerging as a novel therapeutic contribution to tissue regeneration for lung diseases. This study aimed to summarize the advancements in cell therapy involving mesenchymal stromal cells, extracellular vesicles, and immune cells such as T-cells in asthma. Our findings provide evidence that the use of mesenchymal stem cells, their derivatives, and immune cells such as T-cells are an initial milestone to understand how emergent cell-based therapies are effective to face the challenges in the development, progression, and management of asthma, thus improving the quality of life.Copyright © 2021 Cereta, Oliveira, Costa, Afonso, Fonseca, de Souza, Silva, Mello, Oliveira and da Palma.
About The Expert
Andressa Daronco Cereta
Vinícius Rosa Oliveira
Ivan Peres Costa
João Pedro Ribeiro Afonso
Adriano Luís Fonseca
Alan Robson Trigueiro de Souza
Guilherme Augusto Moreira Silva
Diego A C P G Mello
Luis Vicente Franco de Oliveira
Renata Kelly da Palma
References
PubMed