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The following is a summary of “Unlocking Longevity in Aesthetic Dermatology: Epigenetics, Aging, and Personalized Care,” published in the March 2025 issue of International Journal of Dermatology Haykal et al. 

The understanding of aging has evolved to emphasize epigenetic factors over genetics, with epigenetic clocks offering a molecular basis for personalized anti-aging interventions in aesthetic dermatology.  

Researchers conducted a retrospective study to analyze the relationship between epigenetic changes, aging, and personalized care in promoting longevity and skin rejuvenation.  

They searched PubMed and other scientific databases to examine epigenetic mechanisms, including DNA methylation and histone modifications, in skin aging. Epigenetic clocks, such as Horvath’s Clock and GrimAge, were specifically analyzed for their role in personalized dermatological treatments (Horvath’s Clock and GrimAge).  

The results showed that epigenetic clocks, including Horvath’s Clock, effectively assessed biological age using methylation markers. Energy-based devices, such as fractional lasers and radiofrequency, promoted collagen synthesis and reduced biological skin age by reversing age-related epigenetic changes. Additionally, lifestyle factors, including diet, sleep, and circadian rhythm alignment, played a vital role in epigenetic aging and skin health.  

Investigators concluded that integrating epigenetics and biological clocks into aesthetic dermatology allows for personalized skin rejuvenation by targeting molecular aging. 

Source: onlinelibrary.wiley.com/doi/full/10.1111/ijd.17725