Photo Credit: Vladyslav Severyn
The following is a summary of “Inner choroidal fibrosis: An optical coherence tomography biomarker of severity in chronic central serous chorioretinopathy,” published in the February 2024 issue of Ophthalmology by Hansraj et al.
Researchers started a retrospective study investigating inner choroidal fibrosis as a potential biomarker in chronic central serous chorioretinopathy (CSC) at a tertiary referral center.
They observed a grey-white subretinal lesion in the macula of five eyes belonging to four patients with chronic central serous CSC, which underwent analysis through multimodal imaging.
The results showed that the lesions appeared hypofluorescent on autofluorescence, fundus fluorescein angiography (FFA), and indocyanine angiography (ICGA). A characteristic heterogeneous, hyper-reflective lesion on optical coherence tomography (OCT) was observed in the inner choroid, corresponding to the white subretinal lesions. This lesion displayed greater reflectivity and thickness than the adjacent compressed choroidal vasculature. Dilated outer pachyvessels were displaced outward or sideways in all cases. Flow void areas were evident in the corresponding lesion on OCT-angiography. The zone of inner choroidal hyper-reflectivity has been termed “inner choroidal fibrosis.” Upon clinical analysis, three patients had a choroidal neovascularization (CNV) history. In two of these cases, the contralateral eye also developed CNV. Focal choroidal excavation was present in three eyes.
Investigators concluded that four chronic CSCR cases identified “inner choroidal fibrosis” visible on enhanced depth/swept source OCT as a potential biomarker, suggesting it might be a consequence of a more severe past disease state.