The following is a summary of “Oxidative stress parameters in women and men with suicidal thoughts and following a suicide attempt, “published in the April 2024 issue of Psychiatry by Lech et al.
Researchers conducted a retrospective study understanding oxidative stress in people with depression and schizophrenia, looking at gender differences and suicidal behavior types.
They studied 120 patients from the Department of Psychiatry who met the inclusion criteria. At the start of the trial, the patients underwent the M.I.N.I 7.0.2 questionnaire (Mini International Neuropsychiatric Interview). In the second phase, venous blood samples were collected for biochemical assessments of oxidative stress parameters.
The results showed that in women, blood plasma redox biomarkers (TOS [total oxidation state] and OSI [TOS/TAC ratio]) increase as suicidal behavior severity rises. No significant changes in SOD (Cu-Zn-superoxide dismutase), GPx (glutathione peroxidase), and GSH (reduced glutathione) were observed between groups with suicidal behavior. Variations in antioxidant parameters were only significant compared to the control group.
Investigators concluded that TOS and OSI might help women at high suicide risk, while antioxidant SOD, GPx, and GSH could identify patients showing suicidal behavior, regardless of severity.
Source: frontiersin.org/journals/psychiatry/articles/10.3389/fpsyt.2024.1382303/full
