Expression of Interleukin-8, Interleukin-12 and Interleukin-13 in Esophageal Squamous Cell Carcinoma: Biomarker Potentiality and Prognostic Significance.

Jun 24, 2024

Experts: Jayasree Talukdar,Abdul Malik,Kangkana Kataki,Bikash Narayan Choudhury,Munindra Narayan Baruah,Mallika Bhattacharyya,Manash Pratim Sarma,Minakshi Bhattacharjee,Mrinmoy Basak,Manash Pratim Kashyap,Sahana Bhattacharjee,Eyashin Ali,Chenole Keppen,Simanta Kalita,Manash Jyoti Kalita,Partha Pratim Das,Gautam Hazarika,Ankur Jyoti Deka,Kalpajit Dutta,Mohammad Ghaznavi Idris,Suhail Akhtar,Subhash Medhi

Interleukin-8 (IL8), Interleukin-12 (IL12) and Interleukin-13 (IL13) are cytokines that play regulatory role in cancer pathogenesis. We analysed their expression profile to evaluate as molecular biomarkers of esophageal squamous cell carcinoma (ESCC) and their association with different parameters and patient survival.
Expression analysis was performed by Real time quantitative polymerase chain reaction and receiver operating characteristic (ROC) curve analysis was done. The expression profiles were associated with different clinicopathological and dietary factors. Survival and hazard analysis were also performed.
IL8 expression showed upregulation in tissue (p = 0.000) and blood samples (p = 0.481), IL12 expression showed downregulation in tissue samples (p = 0.064) and upregulation in blood samples (p = 0.689) and IL13 expression showed upregulation in tissue (p = 0.000) and blood samples (p = 0.006). IL13 expression in tissue showed the highest area under the curve (AUC) value (0.773) for ESCC diagnosis, followed by IL8 expression in tissue (0.704) and IL13 expression in blood (0.643). This study also reveals the correlation of studied cytokines in tissue and blood level. Different clinicopathological and dietary factors showed significant association (p < 0.05) with IL8, IL12 and IL13 expression and with survival of ESCC patients. IL8 expression in blood and IL12 expression in tissue and blood showed significant association (p < 0.05) with patient survival.
Altered expression of IL8, IL12 and IL13 may be associated with ESCC progression. Overexpression of IL8 and IL13 in tissue samples may be potential biomarkers for ESCC screening. Additionally, both survival and hazard analysis data indicate the effects of different parameters on the prognosis of ESCC patients.

© 2024. The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature.

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ABOUT THE EXPERTS

Jayasree Talukdar,Abdul Malik,Kangkana Kataki,Bikash Narayan Choudhury,Munindra Narayan Baruah,Mallika Bhattacharyya,Manash Pratim Sarma,Minakshi Bhattacharjee,Mrinmoy Basak,Manash Pratim Kashyap,Sahana Bhattacharjee,Eyashin Ali,Chenole Keppen,Simanta Kalita,Manash Jyoti Kalita,Partha Pratim Das,Gautam Hazarika,Ankur Jyoti Deka,Kalpajit Dutta,Mohammad Ghaznavi Idris,Suhail Akhtar,Subhash Medhi

Jayasree Talukdar

Department of Bioengineering and Technology, Gauhati University, Gawahati, Assam, India.

Abdul Malik

Department of Pharmaceutics, College of Pharmacy, King Saud University, Riyadh, Saudi Arabia.

Kangkana Kataki

Department of Bioengineering and Technology, Gauhati University, Gawahati, Assam, India.

Bikash Narayan Choudhury

Department of Gastroentrology, Gauhati Medical College and Hospital, Guwahati, Assam, India.

Munindra Narayan Baruah

Department of Head and Neck Oncology, North East Cancer Hospital and Research Institute, Jorabat, Assam, India.

Mallika Bhattacharyya

Department of Gastroentrology, Gauhati Medical College and Hospital, Guwahati, Assam, India.

Manash Pratim Sarma

Program of Biotechnology, Faculty of Science, Assam down town University, Guwahati, Assam, India.

Minakshi Bhattacharjee

Program of Biotechnology, Faculty of Science, Assam down town University, Guwahati, Assam, India.

Mrinmoy Basak

Faculty of Pharmaceutical Sciences, Assam down town University, Guwahati, Assam, India.

Manash Pratim Kashyap

Program of Statistics, Faculty of Science, Assam down town University, Guwahati, Assam, India.

Sahana Bhattacharjee

Department of Statistics, Gauhati University, Gawahati, Assam, India.

Eyashin Ali

Department of Bioengineering and Technology, Gauhati University, Gawahati, Assam, India.

Chenole Keppen

Department of Bioengineering and Technology, Gauhati University, Gawahati, Assam, India.

Simanta Kalita

Department of Bioengineering and Technology, Gauhati University, Gawahati, Assam, India.

Multidisciplinary Research Unit, Diphu Medical College and Hospital, Karbi Anglong, Assam, India.

Manash Jyoti Kalita

Department of Bioengineering and Technology, Gauhati University, Gawahati, Assam, India.

Partha Pratim Das

Multidisciplinary Research Unit, Fakhruddin Ali Ahmed Medical College and Hospital, Barpeta, Assam, India.

Gautam Hazarika

Department of Bioengineering and Technology, Gauhati University, Gawahati, Assam, India.

Ankur Jyoti Deka

Department of Bioengineering and Technology, Gauhati University, Gawahati, Assam, India.

Kalpajit Dutta

Department of Bioengineering and Technology, Gauhati University, Gawahati, Assam, India.

Mohammad Ghaznavi Idris

Department of Bioengineering and Technology, Gauhati University, Gawahati, Assam, India.

Suhail Akhtar

A. T. Still University of Health Sciences, Kirksville, MO, USA.

Subhash Medhi

Department of Bioengineering and Technology, Gauhati University, Gawahati, Assam, India. subhashmedhi@gauhati.ac.in.