PrEP drastically reduces HIV transmission risk by 99% if used correctly, yet it remains underused by MSM, according to study findings published online in AIDS and Behavior. The study, led by Krishna Kiran Kota, PhD, MS, and colleagues, explored reasons for PrEP refusal among MSM who declined daily oral PrEP when offered by providers. Data from 93 MSM across Atlanta, Chicago, and Raleigh-Durham incorporated surveys, interviews (51 participants), and focus groups (42 participants) and revealed key themes, the authors said. Many participants cited low perceived risks of HIV acquisition (33%) and confidence in other preventive measures like condom use (81%) or monogamy (26%). Factors such as regular HIV testing (18%) also influenced decisions. These findings underscore the importance of ongoing discussions between providers and patients about PrEP’s effectiveness and its role alongside other prevention strategies.