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The following is a summary of “Predicting factors for unresolved premature ventricular complexes in healthy children,” published in the February 2025 issue of BMC Pediatrics by Choi et al.
Premature ventricular complexes (PVCs) are usually benign in healthy children. Some cases show a high PVC burden linked to ventricular tachycardia or dysfunction.
Researchers conducted a retrospective study on PVCs in healthy children and found that older age at onset and female sex predicted unresolved cases.
They analyzed demographic and clinical data from children <18 years with PVCs, including 12-lead electrocardiogram (ECG) and 24-h Holter monitoring.
The results showed that 113 children (mean age 8.35 ± 5.28 years, 71 males [62.8%]) were included with a mean follow-up of 44.9 ± 44.8 months. Initial PVC burden was 13.54 ± 12.53%. During follow-up, 44.2% had complete improvement, 13.3% partial, and 42.5% persistent. Older age at onset (per 1-year increase: OR 1.09, 95% CI: 1.01–1.18, P = 0.027) and female sex (OR 2.25, 95% CI: 1.00–5.06, P = 0.050) were linked to unresolved PVCs.
Investigators found that older age at onset and female sex predicted unresolved PVCs, emphasizing the need for tailored monitoring despite the overall favorable prognosis.
Source: bmcpediatr.biomedcentral.com/articles/10.1186/s12887-025-05516-9
