A higher risk for chronic kidney disease (CKD) is associated with genetically predicted psoriasis, according to a study published in Nephrology. Using data from NHANES, researchers conducted a population-based cross-sectional study (N=16,750) to measure a potential link between psoriasis and CKD risk. A Mendelian randomization (MR) analysis of psoriasis and CKD was used to assess causality. The primary method used was inverse variance-weighted (IVW) analysis. Overall, 9.1% pf patients with psoriasis had CKD compared with 9.1% without psoriasis. Psoriasis was not linked with CKD (OR, 0.77; 95% CI, 0.53-1.10) in the fully adjusted model. In the MR analysis, 36 single-nucleotide polymorphisms (SNPs) were selected as instrumental variables. The IVW analysis revealed that genetically predicted psoriasis was linked with a higher risk for CKD (OR, 1.025; 95% CI, 1.001-1.049). The link remained (OR, 1.028; 95% CI, 1.006-1.050) after removing two SNPs linked with heterogeneity.
