Genome analysis of a novel avian atadenovirus reveals a possible horizontal gene transfer.

Feb 19, 2024

Experts: Weibo Zheng, Xiaopeng Teng, Tingshu Jiang, Wenli Tang, Linlin Jiang, Hongwei Zhu, Xin Yu, Guozhong Chen, Jiao Wang, Jianlong Zhang, Mingjuan Qu, Xingxiao Zhang

We report the discovery and characterization of a novel adenovirus, Zoothera dauma adenovirus (ZdAdV), from a wild bird species, Zoothera dauma (Scaly thrush). This new atadenovirus was discovered by metagenomic sequencing without virus cultivation. Analyses of the full genome sequence revealed that this new virus is a distinct member of the genus Atadenovirus and represents a novel species. ZdAdV has a genome of 34,760 bp with 28 predicted genes and 39% GC content. ZdAdV is the first atadenovirus to contain ORF19, a gene previously found only in aviadenoviruses. Phylogenetic analysis of ORF19 suggests that it was acquired by ZdAdV through horizontal gene transfer from an aviadenovirus. By analyzing all orthologous genes of aviadenovirus, mastadenovirus, atadenovirus, and siadenovirus, we also found potential horizontal gene transfer for the E4 gene in Pigeon aviadenovirus B. Our study widens our knowledge concerning the genetic diversity and evolutionary history of atadenoviruses and their potential for cross-species transmission.
Copyright © 2024. Published by Elsevier Inc.

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ABOUT THE EXPERTS

Weibo Zheng, Xiaopeng Teng, Tingshu Jiang, Wenli Tang, Linlin Jiang, Hongwei Zhu, Xin Yu, Guozhong Chen, Jiao Wang, Jianlong Zhang, Mingjuan Qu, Xingxiao Zhang

Weibo Zheng

School of Life Sciences, Ludong University, Yantai 264000, Shandong, China; Yantai Key Laboratory of Animal Pathogenetic Microbiology and Immunology, Yantai 264000, Shandong, China; Shandong Breeding Environmental Control Engineering Laboratory, Yantai 264000, Shandong, China.

Xiaopeng Teng

Department of Pharmacy, Yantai Yuhuangding Hospital, Yantai 264000, Shandong China.

Tingshu Jiang

Department of Pulmonary and Critical Care Medicine, Yantai Yuhuangding Hospital, Yantai 264000, Shandong China.

Wenli Tang

Shandong Provincial Key Laboratory of Quality Safety Monitoring and Risk Assessment for Animal Products, Jinan 250022, Shandong, China.

Linlin Jiang

School of Life Sciences, Ludong University, Yantai 264000, Shandong, China; Yantai Key Laboratory of Animal Pathogenetic Microbiology and Immunology, Yantai 264000, Shandong, China; Shandong Breeding Environmental Control Engineering Laboratory, Yantai 264000, Shandong, China.

Hongwei Zhu

School of Life Sciences, Ludong University, Yantai 264000, Shandong, China; Yantai Key Laboratory of Animal Pathogenetic Microbiology and Immunology, Yantai 264000, Shandong, China; Shandong Breeding Environmental Control Engineering Laboratory, Yantai 264000, Shandong, China.

Xin Yu

School of Life Sciences, Ludong University, Yantai 264000, Shandong, China; Yantai Key Laboratory of Animal Pathogenetic Microbiology and Immunology, Yantai 264000, Shandong, China; Shandong Breeding Environmental Control Engineering Laboratory, Yantai 264000, Shandong, China.

Guozhong Chen

School of Life Sciences, Ludong University, Yantai 264000, Shandong, China; Yantai Key Laboratory of Animal Pathogenetic Microbiology and Immunology, Yantai 264000, Shandong, China; Shandong Breeding Environmental Control Engineering Laboratory, Yantai 264000, Shandong, China.

Jiao Wang

School of Life Sciences, Ludong University, Yantai 264000, Shandong, China; Yantai Key Laboratory of Animal Pathogenetic Microbiology and Immunology, Yantai 264000, Shandong, China; Shandong Breeding Environmental Control Engineering Laboratory, Yantai 264000, Shandong, China.

Jianlong Zhang

School of Life Sciences, Ludong University, Yantai 264000, Shandong, China; Yantai Key Laboratory of Animal Pathogenetic Microbiology and Immunology, Yantai 264000, Shandong, China; Shandong Breeding Environmental Control Engineering Laboratory, Yantai 264000, Shandong, China.

Mingjuan Qu

School of Life Sciences, Ludong University, Yantai 264000, Shandong, China; Yantai Key Laboratory of Animal Pathogenetic Microbiology and Immunology, Yantai 264000, Shandong, China; Shandong Breeding Environmental Control Engineering Laboratory, Yantai 264000, Shandong, China. Electronic address: qumingjuan@ldu.edu.cn.

Xingxiao Zhang

School of Life Sciences, Ludong University, Yantai 264000, Shandong, China; Yantai Key Laboratory of Animal Pathogenetic Microbiology and Immunology, Yantai 264000, Shandong, China; Shandong Breeding Environmental Control Engineering Laboratory, Yantai 264000, Shandong, China. Electronic address: zhangxingxiao@ldu.edu.cn.