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The following is a summary of “Effect of glucomannan supplementation on lipid profile in adults: a GRADE-assessed systematic review and meta-analysis,” published in the October 2024 issue of Cardiology by Musazadeh et al.
Glucomannan has been evaluated for its health benefits. In adults, the effect of total cholesterol (TC), low-density lipoprotein cholesterol (LDL-C), and triglycerides (TG) on lipid profiles is unclear.
Researchers conducted a retrospective study evaluating the impact of glucomannan supplementation on lipid profiles.
They conducted a comprehensive search across multiple databases, including PubMed, Scopus, Embase, and Web of Science, from inception to June 2024 and analyzed data using random effects models to calculate standardized mean differences (SMDs) and 95% CIs for lipid biomarkers (P 0.001).
The results showed glucomannan significantly decreased TC (SMD: -3.299; 95% CI: -4.955, -1.664, P<0.001; I2= 95.41%, P-heterogeneity < 0.001), LDL-C (SMD: -2.993; 95% CI: -4.958, -1.028; P=0.006; I2 = 95.49%, P-heterogeneity < 0.001), and Apo B1 (SMD: -2.2; 95% CI: -3.58, -0.82; P=0.01). However, this did not significantly affect TG (SMD: -0.119; 95% CI: -1.076, 0.837, P=0.789; I2 = 91.63%, P-heterogeneity < 0.001) or other lipid ratios.
They concluded that adults who consumed glucomannan supplements significantly reduced the TC and LDL-C levels.
Source: bmccardiovascdisord.biomedcentral.com/articles/10.1186/s12872-024-04223-0
