In recent years, there has been a notable and concerning rise in the prevalence of mental disorders, indicating a growing societal challenge that warrants attention and support for affected individuals. Psychiatric problems range on a wide spectrum from as little as work or school related stress to as big as severe depression related to the loss of a loved one, a sense of loneliness, etc. This current generation yields the highest amounts of mental disorder patients due to the newfound pressures, difficulties, and ways of life. According to the Center for Disease Control and Prevention (CDC), more than 1 in 5 U.S. adults live with a mental illness and about 1 in 25 U.S. adults live or lived with a serious mental illness such as schizophrenia, bipolar disorder, or major depression. A similar statistic shows us that about 695,000 people in the U.S. in 2021 died due to some form of heart related disease. That’s 1 in every 5 deaths. More recently, it has been noticed that these psychiatric disorders and heart diseases could be correlated. In this manuscript, we review the current literature on the effect and correlation of psychiatric disorders on the cardiovascular system. We present a review on primarily the “5 major psychiatric disorders,” according to the NIH: depression, autism, ADHD, bipolar disorder, and schizophrenia (Table 1). We will also present a review on stress-induced cardiac diseases, especially more recently with the rise of the COVID-19 Pandemic.Copyright © 2023. Published by Elsevier Inc.