It is the goal of this study to explore retreatment management following failure of different minimally invasive treatments (MIST). A failed MIST is defined by the recurrence, persistence, or worsening of LUTS as measured by symptom ratings. When comorbidities such as recurrent urinary tract infections (UTIs), urinary stone formation and incontinence persist or develop, a failed MIST may be the result.
A long-term bladder outlet obstruction (BOO) is the most common cause of MIST failure before surgery. If the post-void bladder residual (PVR) is low, close monitoring of treatments with antimuscarinics or beta-agonists might be used experimentally. If the PVR is high, urodynamic tests and cystoscopy can be utilised to diagnose overactive bladder (OAB), BOO, or necrosis. Depending on the time of the observed BOO/OAB, further retreatments including transurethral debridement, medicinal and behavioural therapy, or repeat surgical debulking may be used.
Reference: https://link.springer.com/article/10.1007/s11934-021-01054-w
