Preeclampsia is a complication characterized by the more than the normal range of blood pressure of a pregnant woman, usually after twenty weeks of the pregnancy resulting in damage to different organs and organ systems. As it is a fairly common pregnancy complication, many types of research take place on proper treatments.
The researchers did this study to detect the role of endothelial progenitor cells (EPCs) treated with platelet microparticles (PMPs) in preeclampsia.
EPCs treated with/without PMPs were labeled, and then researchers injected them into PE rats. The differentiation of EPCs, the change of endothelial nitric oxide synthase (eNOS), blood pressure, and proteinuria were the main focus variables; therefore, they were measured. The blood pressure and proteinuria increased in each of the PE groups and improved by EPCs, which were strengthened due to PMPs. Transplantation of EPCs increased placental angiogenesis. The trend of change of NO was the same as blood pressure.
The study concluded through its findings that the transplantation of endothelial progenitor cells (EPCs) treated with platelet microparticles (PMPs) improved blood pressure and proteinuria more effectively.
Reference: https://www.tandfonline.com/doi/full/10.1080/10641955.2020.1833914
