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The following is a summary of “Stomach and duodenal ulcer as a cause of death in patients with cancer: a cohort study,” published in the December 2024 issue of Emergency Medicine by Odat et al.
Researchers conducted a retrospective study to identify individuals with cancer at the highest risk of death from stomach and duodenal ulcers.
They retrieved data on individuals diagnosed with cancer between 2000 and 2021 from the Surveillance, Epidemiology, and End Results (SEER) database. Information on causes of death and clinicopathological characteristics, including sex, age, race, marital status, SEER stage, and treatment details, was extracted and SEER*Stat software V8.4.3 was utilized to calculate standardized mortality ratios (SMRs).
The results showed that among 6,89,1191 individuals with cancer, 2,318 deaths were attributed to stomach and duodenal ulcers, reflecting a higher rate than the general population (SMR = 1.58, 95% CI [1.52–1.65]). Deaths from stomach and duodenal ulcers declined over time, from 870 cases between 2000 and 2004 to 294 cases between 2015 and 2019. Of the 2,318 deaths, the highest counts were recorded in individuals with lung and bronchus cancer (n = 255, 11%) and prostate cancer (n = 389, 16.8%). Those with liver and intrahepatic bile duct cancers (SMR = 10.53, 95% CI [8.3–13.18]) and pancreatic cancer (SMR = 6.84, 95% CI [5.11–8.97]) experienced significantly higher death rates from stomach and duodenal ulcers compared to the general population.
Investigators concluded the patients with cancer in the United States exhibited higher stomach and duodenal ulcer mortality, necessitating an integrated care approach to address both cancer and ulcer-related complications, including targeted prevention protocols.
Source: intjem.biomedcentral.com/articles/10.1186/s12245-024-00795-y
