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During 2023, there were increases in the incidences of certain foodborne disease, which may reflect changes in diagnostic practices, according to research published in Morbidity and Mortality Weekly Report. Hazel J. Shah, MPH, and colleagues summarized preliminary 2023 Foodborne Diseases Active Surveillance Network (FoodNet) data and discussed efforts to increase FoodNet representativeness. The researchers observed increases in the incidences of domestically acquired campylobacteriosis, Shiga toxin-producing Escherichia coli infection, yersiniosis, vibriosis, and cyclosporiasis during 2023 compared with 2016-2018, while the incidences of listeriosis, salmonellosis, and shigellosis remained stable. The incidence and percentage of infections diagnosed by culture-independent diagnostic tests (CIDTs) reported to FoodNet continued to increase during 2023, and there was a decrease seen in the percentage of cases yielding an isolate, affecting observed incidence trends. Since CIDTs allow for diagnosis of infections that would previously have gone undetected, increasing numbers of infections may reflect changing diagnostic practices.