Increasing body mass index (BMI) at age 18 years is associated with development of subsequent site-specific cancers in men, according to a study published online Nov. 6 in Obesity.
Aron Onerup, M.D., Ph.D., from the University of Gothenburg in Sweden, and colleagues examined BMI at age 18 years and incident site-specific cancer (malignant melanoma; leukemia; myeloma; Hodgkin lymphoma; non-Hodgkin lymphoma; and cancer in the lungs, head and neck, central nervous system, thyroid, esophagus, stomach, pancreas, liver and gallbladder, colon, rectum, kidney, and bladder) to estimate population attributable fractions due to BMI based on projected obesity prevalence. The analysis included 1.5 million men.
The researchers found that 78,217 men subsequently developed cancer during a mean 31 years of follow-up. There was a linear association between BMI and the risk for developing all 18 site-specific cancers assessed. In some instances, there was an association even with BMI levels usually defined as normal (20 to 25 kg/m2). For prostate cancer, there was an inverse association observed, with higher BMI associated with lower risk. Gastrointestinal cancers had the highest hazard ratios and population attributable fractions.
