For patients with T2D, insulin resistance is associated with the risk for stroke and death, according to a study presented at the annual meeting of the European Association for the Study of Diabetes. Investigators examined the potential association between insulin resistance as measured by estimated glucose disposal rate (eGDR) and the risk for first stroke and death in 104,697 individuals with T2D. There were 4,201 strokes (4%) during a median follow-up of 5.6 years. After multivariable adjustment, the HRs for stroke were 0.77, 0.68, and 0.60 for eGDRs of 4.00-5.99 mg/kg/min, 6.00-7.99 mg/kg/min, and 8.00 mg/kg/min or greater, respectively, compared with the reference of less than 4.00 mg/kg/min. Regarding risk for death, the corresponding HRs were 0.83, 0.77, and 0.72.
