Intact Mismatch Negativity Responses in Clinical High-Risk for Psychosis and First-Episode Psychosis: Evidence from Source-Reconstructed Event-Related Fields and Time-Frequency Data.

Oct 02, 2023

Experts: Pradeep Dheerendra,Tineke Grent-'t-Jong,Ruchika Gajwani,Joachim Gross,Andrew I Gumley,Rajeev Krishnadas,Stephen M Lawrie,Matthias Schwannauer,Frauke Schultze-Lutter,Peter J Uhlhaas

To examine whether Mismatch Negativity (MMN) Responses are impaired in participants at clinical high-risk for psychosis (CHR-P) and first episode psychosis (FEP) patients and whether MMN-deficits predict clinical outcomes in CHR-Ps.
Magnetoencephalography (MEG) data were collected during a duration-deviant MMN-paradigm for a group of 116 CHR-P participants, 33 FEP patients, (15 antipsychotic-naïve), a psychosis-risk-negative group (CHR-N: n=38) with substance abuse and affective disorder and 49 healthy controls (HC). Analysis of group differences of source-reconstructed event-related fields as well as time-frequency and inter-trial-phase-coherence (ITPC) focused on bilateral Heschl’s gyri and superior temporal gyri.
Significant MMNm responses were found across participants in bilateral Heschl’s gyrus and superior temporal gyri. However, MMN-amplitude as well as time-frequency and ITPC-responses were intact in CHR-P and FEP-patients relative to HC. Furthermore, MMN-deficits were not related to persistent attenuated psychotic symptoms nor transitions to psychosis in CHR-Ps.
Our data suggest that MMNm responses in MEG-data are not impaired in early-stage psychosis and may not predict clinical outcomes in CHR-P participants.

Copyright © 2023. Published by Elsevier Inc.

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ABOUT THE EXPERTS

Pradeep Dheerendra,Tineke Grent-'t-Jong,Ruchika Gajwani,Joachim Gross,Andrew I Gumley,Rajeev Krishnadas,Stephen M Lawrie,Matthias Schwannauer,Frauke Schultze-Lutter,Peter J Uhlhaas

Pradeep Dheerendra

School of Psychology and Neuroscience, University of Glasgow, Glasgow, U.K.

Tineke Grent-‘t-Jong

School of Psychology and Neuroscience, University of Glasgow, Glasgow, U.K; Department of Child and Adolescent Psychiatry, Charité Universitätsmedizin, Berlin, Germany.

Ruchika Gajwani

Mental Health and Wellbeing, Institute of Health and Wellbeing, University of Glasgow, Glasgow, U.K.

Joachim Gross

School of Psychology and Neuroscience, University of Glasgow, Glasgow, U.K; Institute for Biomagnetism and Biosignalanalysis, University of Muenster, Muenster, Germany.

Andrew I Gumley

Mental Health and Wellbeing, Institute of Health and Wellbeing, University of Glasgow, Glasgow, U.K.

Rajeev Krishnadas

School of Psychology and Neuroscience, University of Glasgow, Glasgow, U.K.

Stephen M Lawrie

Department of Psychiatry, University of Edinburgh, Edinburgh, U.K.

Matthias Schwannauer

Department of Clinical Psychology, University of Edinburgh, Edinburgh, U.K.

Frauke Schultze-Lutter

Department of Psychiatry and Psychotherapy, Medical Faculty, Heinrich Heine University, Düsseldorf, Germany; Department of Psychology, Faculty of Psychology, Airlangga University, Surabaya, Indonesia; University Hospital of Child and Adolescent Psychiatry and Psychotherapy, University of Bern, Bern, Switzerland.

Peter J Uhlhaas

School of Psychology and Neuroscience, University of Glasgow, Glasgow, U.K; Department of Child and Adolescent Psychiatry, Charité Universitätsmedizin, Berlin, Germany. Electronic address: peter.uhlhaas@charite.de.