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The following is a summary of “Association between magnesium depletion score and prevalence of hyperuricemia in American adults: a study based on NHANES 2007-2018,” published in the February 2025 issue of Endocrinology by Xiao et al. 

The Magnesium Depletion Score (MDS), a novel composite indicator assessing systemic magnesium depletion, has not yet been explored for its association with hyperuricemia (HUA) prevalence.  

Researchers conducted a retrospective study to investigate the relationship between MDS and the prevalence of HUA.  

They used data from the 2007-2018 National Health and Nutrition Examination Survey (NHANES) to examine the relationship between MDS and HUA. The MDS was derived by integrating factors such as diuretic and proton pump inhibitor (PPI) use, estimated glomerular filtration rate (eGFR), and excessive alcohol consumption. The association between MDS and HUA was evaluated through univariable and multivariable logistic regression models. Sensitivity and subgroup analyses, including the exclusion of patients with gout, were also performed.  

The results showed that among 18,761 participants, a higher MDS was linked to an increased prevalence of HUA. Multivariable logistic regression revealed a positive association between MDS and HUA (OR = 1.73, 95% CI = 1.62-1.84). Restricted cubic splines (RCS) demonstrated a non-linear relationship between MDS and HUA prevalence. Subgroup analysis found a positive association with significant interactions between sex and body mass index. Sensitivity and additional analyses confirmed the robustness of these findings.  

Investigators concluded the higher MDS were associated with increased prevalence of HUA among U.S. adults, indicating that addressing magnesium deficiency could help reduce HUA prevalence. 

Source: frontiersin.org/journals/endocrinology/articles/10.3389/fendo.2025.1438639/abstract