Nearly one-quarter of patients with Barrett esophagus with esophageal adenocarcinoma (EAC) had normal endoscopic screenings within the prior year, according to a study published in Gastroenterology. Sachin Wani, MD, and colleagues examined associations between postendoscopy esophageal adenocarcinoma (PEEC) and postendoscopy esophageal neoplasia (PEEN) outcomes with Barrett esophagus. The analysis included 20,588 patients with newly diagnosed Barrett esophagus. Among the 293 patients diagnosed with EAC, 23.5% were categorized as PEEC, 14.7% as index EAC, and 61.8% as incident EAC. For PEEC and incident EAC, the incident rates were 392 and 208 per 100,000 person-years, respectively. Among the 279 patients with high-grade dysplasia (HGD)/EAC, 17.2% were PEEN, 14.6% were index HGD/ EAC, and 68.1% were incident HGD/EAC, with incident rates of 421 per 100,000 person-years for PEEN and 285 for incident HGD/EAC. Results were similar in sensitivity analyses that varied time interval for occurrence of PEEC/ PEEN. A time-trend analysis for incident rates showed increasing incidence rates of PEEC/PEEN.
