This study investigated static and dynamic pupillometry changes before and after ICL V4c implantation under varying light conditions. A prospective study of 210 high myopia patients undergoing V4c ICL implantation was conducted. Pupillometry was performed preoperatively and at 2 weeks, 1 month, and 3 months postoperatively using the Sirius anterior eye segment analysis system (CSO, Florence, Italy). Static parameters (pupil diameter at scotopic, mesopic, and photopic levels) and dynamic parameters (minimum pupil diameter post-light stimulation and dilation velocity) were evaluated. Postoperatively, pupil diameter (PD) decreased significantly under scotopic, mesopic, and photopic conditions but returned to preoperative levels by 1-3 months. Minimum PD after light stimulation and dilation velocity remained unchanged. Pupil center coordinates shifted inferotemporally and gradually approached the corneal center. Scotopic and photopic vaults positively correlated with PD under all light conditions but showed no correlation with minimum PD or dilation velocity. ICL V4c implantation transiently reduces pupil diameter under all light conditions, with recovery to baseline by 1-3 months. Pupil center shifts inferotemporally and approaches the corneal center, while vaults correlate with PD but not dynamic pupillary parameters. The ethics committee of Zhengzhou University’s First Affiliated Hospital gave its approval to this study (2024-KY-0561).
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