Many treatments were tested to be regulatory intervention for oxidative stress and apoptosis. This study investigates melatonin’s effects on cardiac oxidative stress and apoptosis in RUPP rats’ fetal heart.
The researchers did this study using an experimental design. For data collection, the fetal heart samples were obtained from melatonin administered RUPP rats.
Our results obtained after the analysis of the fetal heart samples were obtained from melatonin administered RUPP rats indicate that preeclampsia exacerbated by melatonin deficiency triggers hypoxic conditions, both unfolded protein response, oxidative stress-induced DNA damage, and apoptosis. Melatonin treatment provided significant therapeutic effects on fetal hearts via regulating all these stress responses at cellular and molecular levels.
The study concluded through its findings that the Melatonin may be considered a potential molecule for developing preventive strategies to reduce the PE-induced risk of cardiovascular diseases in offspring. Further studies are required to explore the impact of Melatonin on regulating oxidative stress and apoptosis.
Reference: https://www.tandfonline.com/doi/full/10.1080/10641955.2020.1802595
