Men with diabetes have a greater risk for complications than women irrespective of diabetes duration, according to a study in the Journal of Epidemiology & Community Health. Alice A. Gibson and colleagues investigated sex differences in incident microvascular and macrovascular complications. The analysis included 25,713 people with diabetes (aged 45 years and older) who participated in the 45 and Up Study. Age adjusted incidence rates were 37 per 1,000 person-years for CVD, 52 for eye, 21 for lower limb, and 32 for kidney complications. Compared with women, men had a greater risk for CVD (aHR, 1.51), lower limb (aHR, 1.47), and kidney complications (aHR, 1.55), as well as a greater risk for diabetic retinopathy (aHR, 1.14). Over 10 years, 44% of men experienced a CVD complication, 57% an eye complication, 25% a lower-limb complication, and 35% a kidney complication, compared with 31%, 61%, 18%, and 25% of women, respectively. Diabetes duration (<10 vs ≥10 years) had no substantial impact on sex differences.