Ménière’s disease and allergy: Epidemiology, pathogenesis, and therapy.

Sep 25, 2023

Experts: Wandi Xu,Xiaofei Li,Yongdong Song,Ligang Kong,Na Zhang,Jiahui Liu,Guorong Li,Zhaomin Fan,Yafeng Lyu,Daogong Zhang,Haibo Wang,Na Li

The etiology of Ménière’s disease (MD) remains controversial. Allergies are potential extrinsic factors that, in conjunction with underlying intrinsic factors, may cause MD. The link between allergies and MD was first described in 1923. For nearly a century, studies have demonstrated a possible link between allergies and MD, even though a causal relationship has not been definitively determined. Previous reviews have mainly focused on clinical epidemiology studies of patients. In this review, we shed light on the association between allergies and MD not only in terms of its epidemiology, but also from an immunology, pathophysiology, and immunotherapy perspective in both patients and animal models. Patients with MD tend to have a high risk of comorbid allergies or an allergy history, showing positive allergy immunology characteristics. Other MD-related diseases, such as migraine, may also interact with allergies. Allergy mediators such as IgE may worsen the symptoms of MD. Deposits of IgE in the vestibular end organs indicate the ability of the inner ear to participate in immune reactions. Allergic challenges can induce vertigo in animals and humans. Anti-allergy therapy plays a positive role in patients with MD and animal models of endolymphatic hydrops.
© 2023. The Author(s), under exclusive licence to Springer Nature Switzerland AG.

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ABOUT THE EXPERTS

Wandi Xu,Xiaofei Li,Yongdong Song,Ligang Kong,Na Zhang,Jiahui Liu,Guorong Li,Zhaomin Fan,Yafeng Lyu,Daogong Zhang,Haibo Wang,Na Li

Wandi Xu

Department of Otolaryngology-Head and Neck Surgery, Shandong Provincial ENT Hospital, Shandong University, Jinan, Shandong, China.

Laboratory of Vertigo Disease, Shandong Institute of Otorhinolaryngology, Shandong Second Provincial General Hospital, Jinan, Shandong, China.

Xiaofei Li

Department of Otolaryngology-Head and Neck Surgery, Shandong Provincial ENT Hospital, Shandong University, Jinan, Shandong, China.

Laboratory of Vertigo Disease, Shandong Institute of Otorhinolaryngology, Shandong Second Provincial General Hospital, Jinan, Shandong, China.

Shandong Provincial Vertigo & Dizziness Medical Center, Jinan, Shandong, China.

Yongdong Song

Department of Otolaryngology-Head and Neck Surgery, Shandong Provincial ENT Hospital, Shandong University, Jinan, Shandong, China.

Laboratory of Vertigo Disease, Shandong Institute of Otorhinolaryngology, Shandong Second Provincial General Hospital, Jinan, Shandong, China.

Shandong Provincial Vertigo & Dizziness Medical Center, Jinan, Shandong, China.

Ligang Kong

Department of Otolaryngology-Head and Neck Surgery, Shandong Provincial ENT Hospital, Shandong University, Jinan, Shandong, China.

Laboratory of Vertigo Disease, Shandong Institute of Otorhinolaryngology, Shandong Second Provincial General Hospital, Jinan, Shandong, China.

Shandong Provincial Vertigo & Dizziness Medical Center, Jinan, Shandong, China.

Na Zhang

Department of Otolaryngology-Head and Neck Surgery, Shandong Provincial ENT Hospital, Shandong University, Jinan, Shandong, China.

Laboratory of Vertigo Disease, Shandong Institute of Otorhinolaryngology, Shandong Second Provincial General Hospital, Jinan, Shandong, China.

Jiahui Liu

Department of Otolaryngology-Head and Neck Surgery, Shandong Provincial ENT Hospital, Shandong University, Jinan, Shandong, China.

Laboratory of Vertigo Disease, Shandong Institute of Otorhinolaryngology, Shandong Second Provincial General Hospital, Jinan, Shandong, China.

Guorong Li

Department of Otolaryngology-Head and Neck Surgery, Shandong Provincial ENT Hospital, Shandong University, Jinan, Shandong, China.

Laboratory of Vertigo Disease, Shandong Institute of Otorhinolaryngology, Shandong Second Provincial General Hospital, Jinan, Shandong, China.

Zhaomin Fan

Department of Otolaryngology-Head and Neck Surgery, Shandong Provincial ENT Hospital, Shandong University, Jinan, Shandong, China.

Laboratory of Vertigo Disease, Shandong Institute of Otorhinolaryngology, Shandong Second Provincial General Hospital, Jinan, Shandong, China.

Shandong Provincial Vertigo & Dizziness Medical Center, Jinan, Shandong, China.

Yafeng Lyu

Department of Otolaryngology-Head and Neck Surgery, Shandong Provincial ENT Hospital, Shandong University, Jinan, Shandong, China.

Shandong Provincial Vertigo & Dizziness Medical Center, Jinan, Shandong, China.

Daogong Zhang

Department of Otolaryngology-Head and Neck Surgery, Shandong Provincial ENT Hospital, Shandong University, Jinan, Shandong, China. zhangdaogong1978@163.com.

Laboratory of Vertigo Disease, Shandong Institute of Otorhinolaryngology, Shandong Second Provincial General Hospital, Jinan, Shandong, China. zhangdaogong1978@163.com.

Shandong Provincial Vertigo & Dizziness Medical Center, Jinan, Shandong, China. zhangdaogong1978@163.com.

Haibo Wang

Department of Otolaryngology-Head and Neck Surgery, Shandong Provincial ENT Hospital, Shandong University, Jinan, Shandong, China. whboto11@163.com.

Laboratory of Vertigo Disease, Shandong Institute of Otorhinolaryngology, Shandong Second Provincial General Hospital, Jinan, Shandong, China. whboto11@163.com.

Shandong Provincial Vertigo & Dizziness Medical Center, Jinan, Shandong, China. whboto11@163.com.

Na Li

Department of Otolaryngology-Head and Neck Surgery, Shandong Provincial ENT Hospital, Shandong University, Jinan, Shandong, China. linda831223@163.com.

Laboratory of Vertigo Disease, Shandong Institute of Otorhinolaryngology, Shandong Second Provincial General Hospital, Jinan, Shandong, China. linda831223@163.com.

Center of Clinical Laboratory, Shandong Second Provincial General Hospital, Jinan, Shandong, China. linda831223@163.com.