Meta-analysis of personal and familial co-occurrence of Attention Deficit/Hyperactivity Disorder and Bipolar Disorder.

Jan 23, 2023

Experts: Elie Khoury,Eric Acquaviva,Diane Purper-Ouakil,Richard Delorme,Pierre Ellul

Attention Deficit Disorder / Hyperactivity (ADHD) and Bipolar Disorder (BD) are highly comorbid disorders. Studies have raised the hypothesis of shared genetic, neurobiological, and clinical factors. This would entail an excess risk of co-occurrence of both disorders.
We present the first meta-analysis of individual and familial associations between ADHD and BD.
From 2688 references, 59 were included, with a total of 550,379 ADHD patients, 57,799 BD patients and 12,608,137 controls.
Personal history of ADHD increased the risk of BD (OR = 6.06), and conversely individuals with BD had an increased risk of ADHD (OR = 8.94). First-degree relatives of ADHD patients had an increased risk of BD (OR = 1.94). Offspring of individuals with BD had a higher risk for ADHD (OR = 2.33). Finally, first-degree relatives of BD patients had an increased risk of ADHD (OR = 2.71).
We show a clear epidemiological overlap between ADHD and BD, as well as a strong familial association which advocates in favor of a more systematic screening.

Copyright © 2023 Elsevier Ltd. All rights reserved.

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ABOUT THE EXPERTS

Elie Khoury,Eric Acquaviva,Diane Purper-Ouakil,Richard Delorme,Pierre Ellul

Elie Khoury

Child and Adolescent Psychiatry Department, Robert Debré Hospital, APHP, 48 boulevard Sérurier, 75019 Paris, France. Electronic address: elie.khoury@aphp.fr.

Eric Acquaviva

Child and Adolescent Psychiatry Department, Robert Debré Hospital, APHP, 48 boulevard Sérurier, 75019 Paris, France. Electronic address: eric.acquaviva@apfp.fr.

Diane Purper-Ouakil

CHU Montpellier-Saint Eloi Hospital, University of Montpellier, Unit of Child and Adolescent Psychiatry (MPEA1), 80 Av. Augustin Fliche, 34090 Montpellier, France; INSERM CESP U 1018 Psychiatry, Development and Trajectories, France. Electronic address: d-purper_ouakil@chu-montpellier.fr.

Richard Delorme

Child and Adolescent Psychiatry Department, Robert Debré Hospital, APHP, 48 boulevard Sérurier, 75019 Paris, France; Human Genetics and Cognitive Functions, Institut Pasteur, Paris, France. Electronic address: richard.delorme@aphp.fr.

Pierre Ellul

Child and Adolescent Psychiatry Department, Robert Debré Hospital, APHP, 48 boulevard Sérurier, 75019 Paris, France; INSERM Immunology-Immunopathology-Immunotherapy (i3), UMRS 959, Paris, France. Electronic address: pierre.ellul@aphp.fr.