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Modulation of the gut microbiota engages antigen cross-presentation to enhance antitumor effects of CAR T cell immunotherapy.

Jan 16, 2023

ABOUT THE EXPERTS

  • Mireia Uribe-Herranz

    Division of Radiation Oncology, Hospital of the University of Pennsylvania; Philadelphia, PA, 19104, USA; August Pi i Sunyer Biomedical Research Institute (IDIBAPS), Immunology Department, Hospital Clínic of Barcelona, Barcelona, 08036, Spain.

    Silvia Beghi

    Center for Cellular Immunotherapies, University of Pennsylvania School of Medicine; Philadelphia, PA, 19104, USA; Division of Radiation Oncology, Hospital of the University of Pennsylvania; Philadelphia, PA, 19104, USA.

    Marco Ruella

    Center for Cellular Immunotherapies, University of Pennsylvania School of Medicine; Philadelphia, PA, 19104, USA; Division of Hematology-Oncology, Department of Medicine, University of Pennsylvania School of Medicine; Philadelphia, PA, 19104, USA; Lymphoma Program, Abramson Cancer Center, University of Pennsylvania; Philadelphia, PA, 19104, USA.

    Kalpana Parvathaneni

    Center for Cellular Immunotherapies, University of Pennsylvania School of Medicine; Philadelphia, PA, 19104, USA; Department of Pathology and Laboratory Medicine, Perelman School of Medicine, University of Pennsylvania; Philadelphia, PA, 19104, USA.

    Silvano Salaris

    Unit of Biostatistics, Epidemiology and Public Health, University of Padova, Padova, Italy.

    Nektarios Kostopoulos

    Center for Cellular Immunotherapies, University of Pennsylvania School of Medicine; Philadelphia, PA, 19104, USA; Division of Radiation Oncology, Hospital of the University of Pennsylvania; Philadelphia, PA, 19104, USA.

    Subin S George

    Bioinformatics Core, Institute for Biomedical Informatics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104.

    Stefano Pierini

    Division of Radiation Oncology, Hospital of the University of Pennsylvania; Philadelphia, PA, 19104, USA; The Ovarian Cancer Research Center, University of Pennsylvania; Philadelphia, PA, 19104, USA.

    Elisavet Krimitza

    Center for Cellular Immunotherapies, University of Pennsylvania School of Medicine; Philadelphia, PA, 19104, USA; Division of Radiation Oncology, Hospital of the University of Pennsylvania; Philadelphia, PA, 19104, USA.

    Francesca Costabile

    Center for Cellular Immunotherapies, University of Pennsylvania School of Medicine; Philadelphia, PA, 19104, USA; Division of Radiation Oncology, Hospital of the University of Pennsylvania; Philadelphia, PA, 19104, USA.

    Guido Ghirardi

    Center for Cellular Immunotherapies, University of Pennsylvania School of Medicine; Philadelphia, PA, 19104, USA; Division of Hematology-Oncology, Department of Medicine, University of Pennsylvania School of Medicine; Philadelphia, PA, 19104, USA; Lymphoma Program, Abramson Cancer Center, University of Pennsylvania; Philadelphia, PA, 19104, USA.

    Kimberly V Amelsberg

    Center for Cellular Immunotherapies, University of Pennsylvania School of Medicine; Philadelphia, PA, 19104, USA; Division of Hematology-Oncology, Department of Medicine, University of Pennsylvania School of Medicine; Philadelphia, PA, 19104, USA; Lymphoma Program, Abramson Cancer Center, University of Pennsylvania; Philadelphia, PA, 19104, USA.

    Yong Gu Lee

    Center for Cellular Immunotherapies, University of Pennsylvania School of Medicine; Philadelphia, PA, 19104, USA; Division of Hematology-Oncology, Department of Medicine, University of Pennsylvania School of Medicine; Philadelphia, PA, 19104, USA; Lymphoma Program, Abramson Cancer Center, University of Pennsylvania; Philadelphia, PA, 19104, USA.

    Raymone Pajarillo

    Center for Cellular Immunotherapies, University of Pennsylvania School of Medicine; Philadelphia, PA, 19104, USA; Division of Hematology-Oncology, Department of Medicine, University of Pennsylvania School of Medicine; Philadelphia, PA, 19104, USA; Lymphoma Program, Abramson Cancer Center, University of Pennsylvania; Philadelphia, PA, 19104, USA.

    Caroline Markmann

    Center for Cellular Immunotherapies, University of Pennsylvania School of Medicine; Philadelphia, PA, 19104, USA; Department of Pathology and Laboratory Medicine, Perelman School of Medicine, University of Pennsylvania; Philadelphia, PA, 19104, USA.

    Bevin McGettigan-Croce

    Center for Cellular Immunotherapies, University of Pennsylvania School of Medicine; Philadelphia, PA, 19104, USA; Department of Pathology and Laboratory Medicine, Perelman School of Medicine, University of Pennsylvania; Philadelphia, PA, 19104, USA.

    Divyansh Agarwal

    Department of Surgery, Massachusetts General Hospital, Boston MA 02114, USA; Department of Biology, Massachusetts Institute of Technology, Cambridge MA 02142, USA.

    Noelle Frey

    Division of Hematology-Oncology, Department of Medicine, University of Pennsylvania School of Medicine; Philadelphia, PA, 19104, USA.

    Simon F Lacey

    Center for Cellular Immunotherapies, University of Pennsylvania School of Medicine; Philadelphia, PA, 19104, USA; Department of Pathology and Laboratory Medicine, Perelman School of Medicine, University of Pennsylvania; Philadelphia, PA, 19104, USA.

    John Scholler

    Center for Cellular Immunotherapies, University of Pennsylvania School of Medicine; Philadelphia, PA, 19104, USA.

    Khatuna Gabunia

    Center for Cellular Immunotherapies, University of Pennsylvania School of Medicine; Philadelphia, PA, 19104, USA.

    Gary Wu

    Division of Gastroenterology, Perelman School of Medicine, University of Pennsylvania; Philadelphia, Pennsylvania 19104, USA.

    Elise Chong

    Center for Cellular Immunotherapies, University of Pennsylvania School of Medicine; Philadelphia, PA, 19104, USA.

    David L Porter

    Center for Cellular Immunotherapies, University of Pennsylvania School of Medicine; Philadelphia, PA, 19104, USA; Division of Hematology-Oncology, Department of Medicine, University of Pennsylvania School of Medicine; Philadelphia, PA, 19104, USA; Lymphoma Program, Abramson Cancer Center, University of Pennsylvania; Philadelphia, PA, 19104, USA.

    Carl H June

    Center for Cellular Immunotherapies, University of Pennsylvania School of Medicine; Philadelphia, PA, 19104, USA; Division of Hematology-Oncology, Department of Medicine, University of Pennsylvania School of Medicine; Philadelphia, PA, 19104, USA.

    Stephen J Schuster

    Center for Cellular Immunotherapies, University of Pennsylvania School of Medicine; Philadelphia, PA, 19104, USA; Division of Hematology-Oncology, Department of Medicine, University of Pennsylvania School of Medicine; Philadelphia, PA, 19104, USA; Lymphoma Program, Abramson Cancer Center, University of Pennsylvania; Philadelphia, PA, 19104, USA.

    Vijay Bhoj

    Center for Cellular Immunotherapies, University of Pennsylvania School of Medicine; Philadelphia, PA, 19104, USA; Department of Pathology and Laboratory Medicine, Perelman School of Medicine, University of Pennsylvania; Philadelphia, PA, 19104, USA.

    Andrea Facciabene

    Center for Cellular Immunotherapies, University of Pennsylvania School of Medicine; Philadelphia, PA, 19104, USA; Division of Radiation Oncology, Hospital of the University of Pennsylvania; Philadelphia, PA, 19104, USA; The Ovarian Cancer Research Center, University of Pennsylvania; Philadelphia, PA, 19104, USA. Electronic address: Andrea.Facciabene@pennmedicine.upenn.edu.

REFERENCES & ADDITIONAL READING

PubMed

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