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Multivitamin (MV) use is not associated with mortality benefit among US adults, according to a study published online in JAMA Network Open. Study authors estimated the association of MV use with mortality risk, accounting for confounding by healthy lifestyle and reverse causation. The cohort study used data from three US prospective cohort studies, each with baseline MV use assessed from 1993 to 2001 and follow-up MV use assessed from 1998 to 2004; follow-up was for up to 27 years. Data were included for 390,124 adults; during follow-up, there were 164,762 deaths. The researchers found that 49.3% and 42.0% of daily MV users were female and college educated, respectively, compared with 39.3% and 37.9% among nonusers. Overall, 11.0% and 13.0% of daily users and nonusers, respectively, were current smokers. There was no association observed for MV use with lower all-cause mortality risk in the first or second halves of follow-up. For major causes of death and time-varying analyses, hazard ratios were similar.