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The following is a summary of “Prevalence and impact of rapid eye movement sleep behavior disorder in multiple system atrophy: a systematic review and meta-analysis,” published in the October 2024 issue of Neurology by Wang et al.
Multiple system atrophy (MSA) is a neurodegenerative disorder often associated with rapid eye movement sleep behavior disorder (RBD).
Researchers conducted a retrospective study assessing the prevalence and impact of RBD in patients with MSA.
They analyzed studies related to MSA and RBD, searching databases including PubMed, Web of Science, Embase, and Cochrane (N = 598). Data were pooled to calculate the prevalence of RBD, OR, and weighted mean differences (WMD) with 95% CI, and heterogeneity was assessed using the I2 statistic.
The results showed that the prevalence of polysomnography-confirmed RBD in MSA was 79.9% (95% CI, 68.8–89.3%) in the pooled sample 598. Patients with MSA and RBD were significantly younger at examination than those without RBD (WMD −3.26 years, 95% CI −4.99 to −1.53), and the age of disease onset was notably lower in patients with RBD compared to those without RBD (WMD −3.27, 95% CI −5.06 to −1.48). Additionally, RBD was more prevalent among male patients than female patients (OR 2.11, 95% CI 1.31 to 3.39). Patients with MSA and RBD also had significantly higher Unified Multiple System Atrophy Rating Scale (UMSARS) I and IV scores compared to those without RBD (WMD 2.99, 95% CI 0.10 to 4.88, and WMD 0.23, 95% CI 0.03 to 0.43).
They concluded that the prevalence of polysomnography-confirmed RBD in MSA is 79.9%, with patients exhibiting earlier disease onset and more severe manifestations than those without RBD.
Source: frontiersin.org/journals/neurology/articles/10.3389/fneur.2024.1453944/full
