General practitioner-led medication review intervention led to deprescribing and improved self-reported health status in primary care patients without worsening general condition or functional level, according to findings published in Basic and Clinical Pharmacology and Toxicity. According to the study, there is a persistent knowledge gap regarding the effects of deprescribing on healthrelated outcomes. Anne Estrup Olesen, MD, and colleagues used a real-life quality improvement project using a newly developed chronic care model to assess the impact of general practitioner-led medication review intervention focusing on deprescribing affected health-related outcomes. The before and after intervention study, including care for home residents and community-dwelling patients affiliated with a large Danish general practice, had a defined primary outcome of changes in self-reported health status, general condition, and functional level from baseline to 3–4months follow-up. A total of 87 patients completed the follow-up, with 255 medication changes (83% involved deprescribing).
