To identify PCOS in a population of female patients with MAS by retrospective chart review DESIGN: : Retrospective study SETTING: : Academic setting PARTICIPANTS: : All females with a prior diagnosis of MAS who were older than 12 years of age at the time of chart review. Only complete medical records from January 2009 to January 2020 were included in the analysis.
None MAIN OUTCOME MEASURE(S): : Diagnosis of PCOS based on the Rotterdam 2003 criteria.
Seventeen females with MAS were included in the analysis. PCOS appeared to be more prevalent in MAS patients than expected based on population estimates (exact binomial test 0.353; CI 0.142- 0.617, p-value =0.01). The average BMI was not significantly different between MAS patients with or without PCOS (23.38 kg/m vs. 23.44 kg/m, two-sample Wilcoxon rank-sum test with continuity correction, W=29, p=0.733). Most patients (71%) were treated with an aromatase inhibitor and/or a gonadotropin-releasing hormone (GnRH) agonist.
The results of this study suggest that females with MAS have a statistically higher prevalence of PCOS. These findings warrant further studies to determine whether the increased risk of PCOS may be associated with precocious puberty (PP), treatment of PP, or other factors.

Copyright © 2021. Published by Elsevier Inc.

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