Patients with uncontrolled asthma demonstrate a “unique fingerprint” characterized by inflammatory-related metabolites and proteins, indicating a pro-inflammatory environment, according to findings published in Allergy: European Journal of Allergy and Clinical Immunology. María Isabel Delgado-Dorset, PhD-candidate, and colleagues examined metabolic and immunologic routes underlying uncontrolled asthma to understand its mechanisms among 87 patients stratified by treatment response: corticosteroid-controlled (ICS), immunotherapy-controlled, biological controlled, or uncontrolled (UC). The metabolomic analysis demonstrated that the ICS and UC cohorts cluster separately from one another and have the greatest number of significantly distinct metabolites of all comparisons. Metabolite identification and pathway enrichment analysis emphasized heightened levels of lysophospholipids related to inflammatory pathways in the UC group. Similarly, certain proteins were either upregulated or downregulated in the UC group compared with the ICS cohort, suggesting a significant activation of T cells.
