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The following is a summary of “Global and Regional Burden of Bloodstream Infections Caused by Carbapenem-Resistant Gram-Negative Bacteria in 2019: A Systematic Analysis from the MICROBE Database,” published in the December 2024 issue of Infectious Disease by Zha et al.
Researchers conducted a retrospective study to quantify the global and regional burden of bloodstream infections associated with and attributable to carbapenem-resistant Gram-negative bacteria.
They extracted data from the MICROBE database, which provided estimates for 23 pathogens and 88 pathogen-drug combinations across 12 major infectious syndromes globally in 2019. The analysis focused on the number and rate of deaths and disability-adjusted life-years associated with bloodstream infections.
The results showed that bloodstream infections caused approximately 2.91 million deaths globally in 2019 (95% UI, 1.74-4.53 million), with Gram-negative bacteria responsible for 51.1% of these fatalities. An estimated 3,91,800 deaths (95% UI, 221,500-631,400) were linked to carbapenem resistance, accounting for 26.3% of all bloodstream infection-related deaths. South Asia, East Asia, and Eastern Europe experienced the highest burden of carbapenem resistance, while Sub-Saharan Africa had the lowest burden. Acinetobacter baumannii, Klebsiella pneumoniae, and Pseudomonas aeruginosa were the primary carbapenem-resistant pathogens contributing to mortality.
Investigators concluded the substantial global burden of bloodstream infections caused by carbapenem-resistant Gram-negative bacteria, emphasizing the critical need for improved surveillance, infection control, and access to effective antibiotics, particularly in regions with high prevalence.
Source: ijidonline.com/article/S1201-9712(24)00844-0/fulltext
