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The following is a summary of “Prevalence, clinical features, and long-term outcome of patients with primary Sjögren’s syndrome with renal involvement,” published in the February 2025 issue of Scientific Reports by Jeon et al.
Researchers conducted a retrospective study on renal involvement in primary Sjögren’s syndrome (pSS), finding it rare but linked to impaired renal function and lymphoproliferative disease.
They conducted a multicenter, retrospective longitudinal study on 1,306 patients with pSS (mean age 51 ± 12 years; 98% female) and identified 36 (2.8%) with renal involvement. They compared clinical outcomes based on its presence.
The results showed 17 had tubular involvement, 15 had glomerular, one had both, and 3 were unclassified. Anti-La antibodies were associated. Over 5 years, renal function remained stable, but 44% had impairment linked to baseline renal function and hemoglobin. Lymphoproliferative disease (LPD) was more prevalent.
Investigators found renal involvement in pSS was rare but linked to impaired renal function and LPD, emphasizing the need for screening.
Source: nature.com/articles/s41598-025-88368-8
