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The following is a summary of “Risk Factors for Serrated Polyps: Results From a Large, Multicenter Colonoscopy-Based Study,” published in the December 2024 issue of Gastroenterology by Crockett et al.
Serrated polyps (SPs) are precancerous growths in the colon, but the risk factors for their development are not well understood.
Researchers conducted a retrospective study to identify risk factors for SPs in individuals undergoing colonoscopy.
They analyzed data from a multicenter colonoscopy-based study using multivariable analyses to estimate odds ratios (ORs) for sessile serrated lesions (SSLs) and traditional serrated adenomas (TSAs) based on participant characteristics (n=6,078, with 565 individuals having SPs).
The results showed that individuals of the White race were at a higher risk for developing SPs compared to individuals of the Black race (aORs 4.64, 95% CI 1.89–11.41). Additionally, individuals with obesity and those who currently smoke had a higher likelihood of developing SPs. Furthermore, these factors were significantly associated with the occurrence of SPs in the colon (P<0.01).
They concluded that White race, obesity, and smoking are significant risk factors for SPs, which may assist in identifying individuals at higher risk for colon cancer.
Source: journals.lww.com/ajg/abstract/2024/12000/risk_factors_for_serrated_polyps__results_from_a.33.aspx
