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An estimated one in 20 adults with medically attended RSV experience 28-day hospitalization, according to findings published in JAMA Network Open. Joshua T. Swan, PharmD, MPH, and colleagues examined data from a deidentified Optum dataset, TriNetX Linked, and Veradigm Network Electronic Health Record (VNEHR). The main outcome was all-cause 28-day hospitalization in all adults as well as high-risk subgroups: asthma, COPD, congestive heart failure (CHF), or age ≥65). Among 67,239 cases of medically attended RSV (Optum: 2,771; TriNetX, 7,442; VNEHR, 57,026), the prevalence of comorbidity was 20.0% to 30.5% for COPD, 14.6% to 24.4% for CHF, and 14.6% to 24.4% for asthma; 14.0% to 54.5% of patients were aged 65 and older. The proportion hospitalized was 6.2% (Optum), 6.0% (TriNetX), and 4.5% (VNEHR). In high-risk subgroups, the proportion hospitalized was 7.6% (Optum), 8.5% (TriNetX), and 6.5% (VNEHR). “These results highlight the unmet medical need for outpatient interventions and preventive measures that can reduce hospitalizations,” Dr. Swan and colleagues wrote.