Data indicate that prosthetic vale endocarditis (PVE) is a rare but devastating complication of TAVR. With the belief that understanding PVE in low-risk patients is imperative as indications expand, researchers sought to describe the mechanisms and incidence of PVE in patients in the Low Risk TAVR trials who underwent TAVR from 2016-2020. Among 396 low-risk patients with symptomatic severe aortic stenosis who underwent TAVR, PVE occurred in 11 at a mean of 349 days post-TAVR. In five patients, PVE occurred within 1 year, among whom three showed evidence of septic emboli of the brain and two underwent survival aortic valve re-intervention. Among six patients with PVE after 1 year, three showed evidence of septic emboli to the brain and one underwent surgical aortic valve reintervention. Two patients with late PVE and septic emboli died.
