Self-Adjustment of Deep Brain Stimulation Delays Optimization in Parkinson’s disease.

Apr 15, 2021

Contributor: Lais M Oliveira,Marta Ruiz Lopez,Alexandre Boutet,Gavin J B Elias,Suneil K Kalia,Mojgan Hodaie,Andres M Lozano,Renato P Munhoz,Alfonso Fasano

Self-Adjustment of Deep Brain Stimulation Delays Optimization in Parkinson’s disease.

Parkinson’s Disease patients undergo time-consuming programming to refine stimulation parameters after deep brain stimulation surgery.
To assess whether the use of the advanced functions of a patient’s programmer would facilitate programming of deep brain stimulation.
Thirty patients were randomly allocated to the use of advanced versus simple mode of the patient programmer in this single-centre, prospective, randomized, controlled study. Primary outcome was the number of days required to optimize the stimulation settings.
The number of days required to optimize stimulation was significantly lower in the simple mode (88.5±33.1 vs. 142.1±67.4, p=0.01). In addition, the advanced mode group had a higher number of side effects (5.4±3.1 vs. 2.6±1.9, p=0.0055).
The use of the advanced functions of patient programmer delays programming optimization and it is associated with a higher number of side effects. These findings highlight the need for other methods for faster and safer stimulation programming.

Copyright © 2021. Published by Elsevier Inc.

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About The Expert

Lais M Oliveira

Edmond J. Safra Program in Parkinson’s Disease and Morton and Gloria Shulman Movement Disorders Clinic, Toronto Western Hospital, UHN, Division of Neurology, University of Toronto, Toronto, Ontario, Canada.

Marta Ruiz Lopez

Edmond J. Safra Program in Parkinson’s Disease and Morton and Gloria Shulman Movement Disorders Clinic, Toronto Western Hospital, UHN, Division of Neurology, University of Toronto, Toronto, Ontario, Canada; Neurology Department, Cruces University Hospital, Barakaldo, Bizkaia, Spain.

Alexandre Boutet

Division of Neurosurgery, University Health Network, University of Toronto, Toronto, Ontario, Canada; Joint Department of Medical Imaging, University of Toronto, Toronto, Ontario, Canada.

Gavin J B Elias

Division of Neurosurgery, University Health Network, University of Toronto, Toronto, Ontario, Canada.

Suneil K Kalia

Division of Neurosurgery, University Health Network, University of Toronto, Toronto, Ontario, Canada; Krembil Brain Institute, Toronto, Ontario, Canada.

Mojgan Hodaie

Division of Neurosurgery, University Health Network, University of Toronto, Toronto, Ontario, Canada; Krembil Brain Institute, Toronto, Ontario, Canada.

Andres M Lozano

Division of Neurosurgery, University Health Network, University of Toronto, Toronto, Ontario, Canada; Krembil Brain Institute, Toronto, Ontario, Canada.

Renato P Munhoz

Edmond J. Safra Program in Parkinson’s Disease and Morton and Gloria Shulman Movement Disorders Clinic, Toronto Western Hospital, UHN, Division of Neurology, University of Toronto, Toronto, Ontario, Canada; Krembil Brain Institute, Toronto, Ontario, Canada.

Alfonso Fasano

Edmond J. Safra Program in Parkinson’s Disease and Morton and Gloria Shulman Movement Disorders Clinic, Toronto Western Hospital, UHN, Division of Neurology, University of Toronto, Toronto, Ontario, Canada; Krembil Brain Institute, Toronto, Ontario, Canada; CenteR for Advancing Neurotechnological Innovation to Application (CRANIA), Toronto, ON, Canada. Electronic address: alfonso.fasano@uhn.ca.

References

PubMed