This study’s primary purpose was to investigate the biomarker(s) that could affect the decision for immediate or delayed delivery in severe preeclampsia.
Researchers collected the relevant data on serum levels of alanine aminotransferase (ALT), aspartate aminotransferase (AST), alkaline phosphatase (ALP), creatinine, blood urea nitrogen (BUN), uric acid (UA), and platelet counts from 134 cases. The obtained data was then analyzed to come to clinically useful conclusions.
After careful analysis, the study found that the higher UA levels were seen with immediate delivery. Researchers also observed that the higher stillbirth was seen in cases with delayed delivery.
The study concluded that the UA levels could be a potential management biomarker for immediate or delayed delivery in severe preeclampsia. However, the higher risk of stillbirth must be considered in delayed delivery. Further research on the serum levels of uric acid with other research designs and larger sample size are required to explain the phenomena in-depth about its potential role in the management of immediate delivery or prolongation of pregnancy in severe preeclampsia.
Reference: https://www.tandfonline.com/doi/full/10.1080/10641955.2020.1761377
