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The following is a summary of “MTNR1B Rs724030 Variant is Associated With Islet Function and Women Waist-to-Hip Ratio (WHR) in Healthy Subjects,” published in the December 2024 issue of Endocrinology by Zhang et al.
The MTNR1B rs724030 A>G genetic variant is associated with pancreatic islet function, glucose regulation, and sex differences in waist-to-hip ratio (WHR) among individuals without diabetes.
Researchers conducted a retrospective study to investigate associations between the MTNR1B rs724030 A>G variant and the risk of prediabetes and glycemic traits and lipid levels in individuals without diabetes.
They analyzed data from 3,415 individuals with normal glucose tolerance and 1,744 individuals with prediabetes, determined by the oral glucose tolerance test (OGTT). Binary logistic regression was used to assess the relationships between the MTNR1B rs724030 variant and prediabetes risk under the additive model, and multiple linear regression examined associations with glycemic-related traits and lipid levels.
The results showed that individuals with the G allele of the MTNR1B rs724030 variant had higher fasting and 30-minute plasma glucose levels and lower Insulinogenic Index (IGI) and oral disposition index (DIo) (P=0.009, 0.001, 0.001, and 0.007, respectively) in individuals with normal glucose tolerance and normal body mass index (BMI). Among women with WHR greater than 0.85, the variant was associated with IGI, corrected insulin response (CIR), and DIo (all P<0.001), with differences compared to men (heterogeneity P=0.009, 0.030, and 0.049, respectively). No association was found between the variant and insulin clearance (all P>0.05).
They concluded that the MTNR1B rs724030 variant was associated with glycemic traits and pancreatic islet function, with sex-specific effects observed in individuals with normal glucose tolerance when stratified by WHR.
Source: frontiersin.org/journals/endocrinology/articles/10.3389/fendo.2024.1398687/abstract
