Women with psoriasis have a significantly increased risk for ectopic pregnancy (EP), which is highest for those with moderate-to-severe disease, according to a study published in JAAD International. Cæcilie Bachdal Johansen, MD, and colleagues examined the association between psoriasis and adverse pregnancy outcomes (APOs) in a nationwide register-based case-control study involving data collected from 1973-2017. Cases were APOs, including spontaneous abortion, EP, intrauterine fetal death, and stillbirth; controls were singleton live births. The only APO that was statistically significantly associated with psoriasis was EP (OR, 1.34). Women with moderate-to-severe psoriasis had the highest OR for EP (OR, 2.77). Compared with those without psoriasis, women with moderate-to-severe psoriasis had a 2.48% higher absolute risk for EP (3.98% vs 1.50%). “Our findings call for particular care for women of reproductive age with psoriasis, that is, informing sexually active patients to seek emergency gynecologic evaluation in case of lower abdominal pain, unplanned absence of menstruation, and concurrent light vaginal bleeding,” the authors wrote.
