It is well-established that cutaneous squamous cell carcinoma (SCC) has a poor prognosis, and this poor prognosis is associated with bone invasion. Despite the rarity of bone-invading SCC, there have been no published survival analyses of the variables associated with this type of cancer. The purpose of this research is to analyze all of the demographic, clinical, and treatment data that is currently available for SCC patients who have a bone invasion to determine the impact that prognostic variables have on the progression of the disease, deaths caused by the disease specifically, and overall mortality rates. An individual patient’s information was taken from each case report and used in a pooled survival analysis. This information was used in a systematic review. The progression-free survival (PFS), disease-specific survival (DSS), and overall survival (OS) were all determined with the help of researchers’ analysis. From a total of 49 distinct studies, investigators extracted 66 cases of SCC that had a bone invasion. The univariable analysis found that tumor recurrence and nonsurgical treatment technique were both significant predictors of disease progression, while the multivariable analysis found that only tumors of the trunk, head, and neck were significant predictors of disease progression. Patients had a PFS of 66.7%, a DSS of 71.7%, and an OS of 66.2% 5 years after their diagnosis of bone invasion. DFS, DSS, and OS rates were all low for cases of SCC with bone invasion; results were even worse for tumors located in the trunk, head, and neck.
