2MM
Ribociclib plus letrozole provides greater overall survival benefit advanced breast cancer
1. Ribociclib plus letrozole provides significant overall survival benefit as compared to...
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Breast cancer overdiagnosis rates not as high as estimated previously
1. About 1 in 7 cases of screen-detected cancer is overdiagnosed in the US population. 2. The rate...
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Overdoses in youth with benzodiazepine and stimulant prescriptions
1. A retrospective analysis found that 29% of youth with benzodiazepine overdose and 25% of youth...
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Systematic review and meta-analysis of statin-induced reduction in LDL-C demonstrates modest absolute benefits
1. This systematic review and meta-analysis found a modest absolute risk reduction of 0.8% in...
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Accessible hepatitis C care for people who inject drugs provide significantly higher rates of cure compared to conventional care
1. In patients with hepatitis C virus who recently injected drugs, 67% in the accessible care arm...
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Non-severe tuberculosis in children can be treated with a shorter 4-month regimen
1. For children with non-severe tuberculosis, 4 months of antituberculosis treatments was...
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Low- and no-calorie sweetened beverages associated with reduced body weight compared to sugar-sweetened beverages: a systematic review and meta-analysis
1. This systematic review and meta-analysis demonstrated that low- and no-calorie sweetened...
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Garadacimab significantly reduces frequency of hereditary angioedema exacerbations
1. Garadacimab significantly reduced the number of monthly attacks in patients with hereditary...
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Early intervention services for children exposed to lead associated with improved standardized test performance
1. In a retrospective cohort of about 11,000 children with at least one blood lead level above 4...
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Effectiveness of Covid-19 vaccines waned over timer in North Carolina
1. Three Covid-19 vaccines from Pfizer, Moderna, and Johnson & Johnson provided durable...
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Maternal substance use may increase risk of childhood Attention Deficit Hyperactivity Disorder
1. Substance use in the prenatal period may be associated with an increased risk of an Attention...
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Majority of long-acting injectable and oral antipsychotics are similar in efficacy for schizophrenia maintenance therapy
1. There was no evidence of superiority among the different antipsychotics. 2. Choice of...
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Poor sleep quality and pandemic-related perceived threat may exacerbate post-traumatic stress disorder symptoms
1. In this study, baseline poor sleep was associated with more severe PTSD symptoms...
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#VisualAbstract: Differences in Merkel cell carcinoma recurrence and survival rates stratified by cancer stage
Click to read this study in JAMA Dermatology.
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Risk of chronic kidney disease progression may be greater amongst patients with obstructive sleep apnea
1. This study found moderate-to-very high risk of chronic kidney disease progression was greater...
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Postoperative treatment without radioiodine has noninferior outcomes following thyroidectomy
1. Patients with low-risk thyroid cancer undergoing thyroidectomy, who did not receive radioiodine...
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Non-alcoholic fatty liver disease-related hepatocellular carcinoma (HCC) differ clinically compared to HCC due to other causes
1. Patients with NAFLD-related HCC have longer disease-free survival compared to those with HCC...
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Computed tomography a suitable diagnostic alternative for obstructive coronary artery disease
1. For patients referred for potential obstructive coronary artery disease (CAD), computed...
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Pro-inflammatory diets may objectively negatively impact sleep amongst police officers
1. This study showed that more pro-inflammatory diets led to higher wake-after-sleep-onset (WASO)...
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